Resident Population in St. Louis City, MO was 279.69500 Thous. of Persons in January of 2024, according to the United States Federal Reserve. Historically, Resident Population in St. Louis City, MO reached a record high of 622.23600 in January of 1970 and a record low of 279.69500 in January of 2024. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in St. Louis City, MO - last updated from the United States Federal Reserve on April of 2026.